How does aspirin function in the setting of ACS?

Aspirin plays a crucial role in the management of Acute Coronary Syndrome (ACS) primarily by inhibiting cyclooxygenase (COX), an enzyme involved in the production of thromboxane A2, a powerful promoter of platelet aggregation. By inhibiting COX, aspirin effectively reduces the ability of platelets to clump together, which helps prevent the formation of blood clots. Clots can obstruct coronary arteries, leading to myocardial ischemia or infarction.

In ACS, where the risk of clot formation is significantly increased due to plaque rupture or inflammation in the arteries, the antiplatelet effect of aspirin is vital for stabilizing the situation and reducing the risk of further ischemic events. Consequently, this mechanism directly contributes to improved outcomes for patients experiencing ACS.