Elevated levels of troponin, CK, and LDH are indicative of which condition?

Elevated levels of troponin, CK (creatine kinase), and LDH (lactate dehydrogenase) are primarily associated with myocardial infarction, which is a type of acute coronary syndrome. Troponin is a highly specific marker for cardiac muscle damage, and its elevation is the most sensitive indicator of myocardial injury. CK and LDH are also enzymes that can increase in response to myocardial injury, although they are less specific than troponin for cardiac events.

In the context of myocardial infarction, these elevated biomarkers reflect the death of myocardial cells due to a lack of adequate blood flow, typically caused by a blockage in the coronary arteries. This condition leads to ischemia, followed by necrosis if not promptly treated. Therefore, the presence of these markers in significant quantities would confirm that a myocardial infarction has occurred.

To differentiate further, while myocardial ischemia indicates reduced blood flow to the heart muscle, it may not necessarily reflect permanent damage or the elevation of these specific biomarkers. Hypertension is a chronic condition that affects cardiovascular health but does not directly cause elevation in these enzymes acutely. Similarly, while coronary artery disease indicates the presence of atherosclerosis that may lead to myocardial infarction, it does not directly correlate with